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Principles of Receptor Research [electronic resource] / edited by Leslie Iversen.

Contributor(s): Material type: TextSeries: Section I: Basic Neuropharmacology ; 2Publisher: New York, NY : Springer US : Imprint: Springer, 1975Edition: 1st ed. 1975Description: XII, 288 p. online resourceContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781468431681
Subject(s): Additional physical formats: Printed edition:: No title; Printed edition:: No title; Printed edition:: No titleDDC classification:
  • 150 23
LOC classification:
  • BF1-990
Online resources:
Contents:
1 Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs -- 1. Introduction -- 2. Characteristics of the Blood-Brain Barrier -- 3. Bypassing the Blood-Brain Barrier: Principles -- 4. Pharmacological Approach to the Internal or External Surface of the Brain -- 5. Drugs Administered to the Brain Parenchyma -- 6. Concluding Comment -- 7. References -- 2 Microiontophoretic Application of Drugs onto Single Neurons -- 1. Introduction -- 2. Basic Principles -- 3. Dispersal of Iontophoretically Applied Substances Within the Brain -- 4. Conclusions -- 5. References -- 3 Electrical Recording of Brain Activity: The EEG and Its Value in Assessing Drug Effects -- 1. Introduction -- 2. Selection of Animal Species -- 3. Acute Experiments -- 4. Chronic Implantation of Electrodes -- 5. Recording Procedures -- 6. Methods of Analyzing and Quantifying the EEG -- 7. Sensory Evoked Response Analysis -- 8. Focal Electrical Stimulation -- 9. Electrogenesis of the EEG and Evoked Potentials -- 10. Assessment of Alertness, Sedation, and the Stages of Sleep -- 11. Study of Sleep Patterns -- 12. Abnormal EEG Records -- 13. Transmitters and EEG Changes -- 14. Uses and Limitations of Macroelectrode Recordings -- 15. References -- 4 Neuropharmacological Responses from Nerve Cells in Tissue Culture -- 1. Introduction -- 2. Muscle -- 3. Continuous Cell Lines -- 4. Glia -- 5. Explants -- 6. Dissociated Primary Cell Cultures -- 7. Discussion -- 8. References -- 5 Biochemical Identification of Membrane Receptors: Principles and Techniques -- 1. Introduction -- 2. Properties of Receptor Interactions and Technical Considerations -- 3. Examples of Studies on Hormone-Membrane Receptor Interactions -- 4. Conclusions -- 5. References -- 6 Structure-Activity Relations for Neurotransmitter Receptor Agonists and Antagonists -- 1. Introduction -- 2. Norepinephrine -- 3. Dopamine -- 4. 5-Hydroxytryptamine -- 5. Acetylcholine -- 6. Histamine -- 7. References -- 7 Denervation Supersensitivity -- 1. Introduction -- 2. Quantitative Methods in the Study of Supersensitivity -- 3. Surgical and Pharmacological Denervation -- 4. Supersensitivity After Denervation of Sympathetically Innervated Organs -- 5. Supersensitivity After Denervation of Cholinergically Innervated Organs -- 6. Supersensitivity in the Central Nervous System -- 7. Clinical Implications of Supersensitivity and Subsensitivity -- 8. References.
In: Springer Nature eBook
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1 Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs -- 1. Introduction -- 2. Characteristics of the Blood-Brain Barrier -- 3. Bypassing the Blood-Brain Barrier: Principles -- 4. Pharmacological Approach to the Internal or External Surface of the Brain -- 5. Drugs Administered to the Brain Parenchyma -- 6. Concluding Comment -- 7. References -- 2 Microiontophoretic Application of Drugs onto Single Neurons -- 1. Introduction -- 2. Basic Principles -- 3. Dispersal of Iontophoretically Applied Substances Within the Brain -- 4. Conclusions -- 5. References -- 3 Electrical Recording of Brain Activity: The EEG and Its Value in Assessing Drug Effects -- 1. Introduction -- 2. Selection of Animal Species -- 3. Acute Experiments -- 4. Chronic Implantation of Electrodes -- 5. Recording Procedures -- 6. Methods of Analyzing and Quantifying the EEG -- 7. Sensory Evoked Response Analysis -- 8. Focal Electrical Stimulation -- 9. Electrogenesis of the EEG and Evoked Potentials -- 10. Assessment of Alertness, Sedation, and the Stages of Sleep -- 11. Study of Sleep Patterns -- 12. Abnormal EEG Records -- 13. Transmitters and EEG Changes -- 14. Uses and Limitations of Macroelectrode Recordings -- 15. References -- 4 Neuropharmacological Responses from Nerve Cells in Tissue Culture -- 1. Introduction -- 2. Muscle -- 3. Continuous Cell Lines -- 4. Glia -- 5. Explants -- 6. Dissociated Primary Cell Cultures -- 7. Discussion -- 8. References -- 5 Biochemical Identification of Membrane Receptors: Principles and Techniques -- 1. Introduction -- 2. Properties of Receptor Interactions and Technical Considerations -- 3. Examples of Studies on Hormone-Membrane Receptor Interactions -- 4. Conclusions -- 5. References -- 6 Structure-Activity Relations for Neurotransmitter Receptor Agonists and Antagonists -- 1. Introduction -- 2. Norepinephrine -- 3. Dopamine -- 4. 5-Hydroxytryptamine -- 5. Acetylcholine -- 6. Histamine -- 7. References -- 7 Denervation Supersensitivity -- 1. Introduction -- 2. Quantitative Methods in the Study of Supersensitivity -- 3. Surgical and Pharmacological Denervation -- 4. Supersensitivity After Denervation of Sympathetically Innervated Organs -- 5. Supersensitivity After Denervation of Cholinergically Innervated Organs -- 6. Supersensitivity in the Central Nervous System -- 7. Clinical Implications of Supersensitivity and Subsensitivity -- 8. References.

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