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The Immune Response to Implanted Materials and Devices : The Impact of the Immune System on the Success of an Implant.

By: Material type: TextPublisher: Cham : Springer International Publishing AG, 2016Copyright date: ©2017Edition: 1st edDescription: 1 online resource (254 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9783319454337
Subject(s): Genre/Form: DDC classification:
  • 610.28
Online resources:
Contents:
Intro -- Foreword -- Preface -- Contents -- Contributors -- Abbreviations -- Chapter 1: Host Response to Implanted Materials and Devices: An Overview -- 1.1 Introduction -- 1.2 Innate Immune Response to Implanted Materials -- 1.3 Adaptive Immune Response to Implanted Materials -- 1.4 Macrophages and Constructive Remodeling -- 1.5 Host Response to Biologic Versus Synthetic Biomaterials -- 1.5.1 Biologic Versus Synthetic Biomaterials -- 1.5.2 Extracellular Matrix as Biologic Scaffold -- 1.6 Host Response to Orthopedic Implants -- 1.7 Clinical Considerations -- 1.7.1 Designing Materials and Devices for Immunomodulation -- 1.8 Conclusions -- References -- Chapter 2: Implications of the Acute and Chronic Inflammatory Response and the Foreign Body Reaction to the Immune Response of Implanted Biomaterials -- 2.1 Introduction -- 2.2 Blood-Material Interactions/Provisional Matrix Formation -- 2.3 Acute Inflammation -- 2.4 Chronic Inflammation -- 2.5 Granulation Tissue -- 2.6 Foreign-Body Reaction -- 2.7 Fibrosis/Fibrous Encapsulation -- 2.8 Discussion and Perspectives -- 2.9 Conclusions -- References -- Chapter 3: Macrophages: The Bad, the Ugly, and the Good in the Inflammatory Response to Biomaterials -- 3.1 Introduction -- 3.2 Developmental Origin -- 3.2.1 Monocytes and Macrophages Ontogeny and Lineage -- 3.2.2 Monocytes and Macrophages Lineage Regulation -- 3.2.3 Macrophage Function in Development -- 3.3 Macrophages and Inflammation -- 3.3.1 The Wound-Healing Process -- 3.3.2 Macrophages in Wound Healing -- 3.3.3 Regulation and Functional Consequences of Distinct Macrophage Phenotypes -- 3.3.4 Macrophage Phenotype Plasticity -- 3.4 Macrophage Interaction with Biomaterial Implants -- 3.4.1 Macrophage Recruitment to the Biomaterial Surface -- 3.4.2 Macrophage-Derived Foreign Body Giant Cells -- 3.4.3 Macrophages and Fibrosis.
3.5 Strategies to Target Macrophage Function and Polarization in the FBR -- 3.5.1 Macrophages and Biomaterial Biomimicry -- 3.5.2 Biomaterial Modulation of Macrophage Phenotype -- 3.5.3 Macrophage Spatiotemporal Distribution in the FBR -- 3.5.4 Engineering Macrophages to Modulate Inflammation During the FBR -- 3.6 Conclusions -- References -- Chapter 4: Understanding Nanoparticle Immunotoxicity to Develop Safe Medical Devices -- 4.1 Introduction -- 4.2 Hematological Compatibility -- 4.2.1 Hemolysis -- 4.2.2 Thrombogenicity -- 4.2.3 Anticoagulant Activity -- 4.2.4 Complement Activation -- 4.2.5 Protein "Corona" -- 4.3 Effects on the Immune Cell Function -- 4.4 Preclinical Characterization -- 4.4.1 Sterility and Endotoxin -- 4.4.2 Sterilization -- 4.5 Regulatory Considerations -- 4.6 Conclusions -- References -- Chapter 5: Host Response to Synthetic Versus Natural Biomaterials -- 5.1 Introduction -- 5.2 Natural Biomaterials -- 5.2.1 Collagen -- 5.2.2 Gelatin -- 5.2.3 Chitosan -- 5.2.4 Hyaluronan -- 5.2.5 Heparin -- 5.2.6 Alginate -- 5.2.7 Silk -- 5.2.8 Decellularized Tissue Matrices -- 5.3 Synthetic Biomaterials -- 5.3.1 Polyglycolide or Polyglycolic Acid (PGA) -- 5.3.2 Polylactic Acid (PLA) -- 5.3.3 Polycaprolactone (PCL) -- 5.3.4 Polyurethane (PU) -- 5.3.5 Polytetrafluoroethylene (PTFE) -- 5.4 Important Biomaterial Characteristics in the Host Response -- 5.5 Strategies to Overcome and Modulate the Host Responses -- 5.5.1 Surface Modification -- 5.5.2 Surface Coatings -- 5.5.3 Delivery of Bioactive Molecules -- 5.6 Conclusions -- References -- Chapter 6: Convergence of Osteoimmunology and Immunomodulation for the Development and Assessment of Bone Biomaterials -- 6.1 Introduction -- 6.2 Immune Cells Regulate Bone Dynamics -- 6.3 Definition of the "Osteoimmunomodulation" Property.
6.4 The Need to Include Immune Cells When Evaluating Novel Bone Biomaterials -- 6.5 Development of "Smart" Bone Biomaterials to Manipulate Osteoimmunomodulation -- 6.6 Conclusions -- References -- Chapter 7: Modulation of Innate Immune Cells to Create Transplant Tolerance -- 7.1 Introduction -- 7.1.1 Elements of the Innate Immunity -- 7.1.1.1 Innate Molecular Sensors -- 7.1.1.2 Complement -- 7.1.1.3 Innate Immune Cells -- Natural Killer Cells -- Monocytes and Macrophages -- Dendritic Cells -- Other Innate Cells -- 7.1.2 Responses of Innate Cells to Transplants -- 7.1.2.1 Ischemia-Reperfusion Injury -- 7.1.2.2 Acute Transplant Rejection -- 7.1.2.3 Chronic Transplant Rejection -- 7.1.2.4 Transplant Tolerance -- 7.1.3 Future Considerations -- References -- Chapter 8: Inflammatory Cytokine Response to Titanium Surface Chemistry and Topography -- 8.1 Introduction -- 8.2 Implant Surface Modification to Enhance Osseointegration: Influence of Micro-Roughness, Nano-­Roughness and Hydrophilicity -- 8.3 Titanium and Macrophage Polarization -- 8.4 Macrophage Response to Titanium Surface Modification -- 8.5 Topography-Induced Changes in Macrophage Function -- 8.6 Conclusions -- References -- Chapter 9: The Biomechanical Environment and Impact on Tissue Fibrosis -- 9.1 Introduction -- 9.2 Tissue Fibrosis -- 9.3 Implants and Fibrous Capsules -- 9.4 Biomechanical Forces and Tissue Fibrosis -- 9.5 Effects of Tissue Mechanical Properties on Fibrosis -- 9.6 Effects of Mechanical Stretch/Tension on Tissue Fibrosis -- 9.7 Shear Stress and Fibrosis -- 9.8 Mechanical Forces and Inflammation -- 9.9 Transduction of Mechanical Signals -- 9.10 Integration of Mechanical and Biochemical Signals -- 9.11 Conclusions -- References -- Chapter 10: Advancing Islet Transplantation: From Donor to Engraftment -- 10.1 Introduction -- 10.2 Donor Factors -- 10.3 Metabolic Factors.
10.4 Pancreas Procurement and Preservation -- 10.5 Islet Cell Processing -- 10.5.1 Islet Isolation -- 10.5.2 Islet Purification -- 10.5.3 Islet Culture -- 10.5.4 Islet Cell Viability and Functional Assay -- 10.5.5 Islet Vascularization After Transplant -- References -- Chapter 11: Targeted Modulation of Macrophage Functionality by Nanotheranostics in Inflammatory Liver Disease and Cancer -- 11.1 Introduction -- 11.2 Role of Hepatic Macrophages in Inflammation and Cancer -- 11.3 Classifications of Nanomaterials and Nanotheranostics -- 11.4 Targeting of Hepatic Macrophages Using Nanotheranostics -- 11.5 Conclusions -- References -- Chapter 12: T-Cell Mediated Immunomodulation and Transplant Optimization -- 12.1 Introduction -- 12.2 T-Cell Immune Responses and Age -- 12.3 Allogeneic HSCT: The Paradigm and Spearhead of T-Cell Immunotherapy -- 12.4 T-Cell Responses to Implants and Scaffolds: Challenges and Options -- 12.5 Perspectives for Transplant Optimization -- References -- Index.
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Intro -- Foreword -- Preface -- Contents -- Contributors -- Abbreviations -- Chapter 1: Host Response to Implanted Materials and Devices: An Overview -- 1.1 Introduction -- 1.2 Innate Immune Response to Implanted Materials -- 1.3 Adaptive Immune Response to Implanted Materials -- 1.4 Macrophages and Constructive Remodeling -- 1.5 Host Response to Biologic Versus Synthetic Biomaterials -- 1.5.1 Biologic Versus Synthetic Biomaterials -- 1.5.2 Extracellular Matrix as Biologic Scaffold -- 1.6 Host Response to Orthopedic Implants -- 1.7 Clinical Considerations -- 1.7.1 Designing Materials and Devices for Immunomodulation -- 1.8 Conclusions -- References -- Chapter 2: Implications of the Acute and Chronic Inflammatory Response and the Foreign Body Reaction to the Immune Response of Implanted Biomaterials -- 2.1 Introduction -- 2.2 Blood-Material Interactions/Provisional Matrix Formation -- 2.3 Acute Inflammation -- 2.4 Chronic Inflammation -- 2.5 Granulation Tissue -- 2.6 Foreign-Body Reaction -- 2.7 Fibrosis/Fibrous Encapsulation -- 2.8 Discussion and Perspectives -- 2.9 Conclusions -- References -- Chapter 3: Macrophages: The Bad, the Ugly, and the Good in the Inflammatory Response to Biomaterials -- 3.1 Introduction -- 3.2 Developmental Origin -- 3.2.1 Monocytes and Macrophages Ontogeny and Lineage -- 3.2.2 Monocytes and Macrophages Lineage Regulation -- 3.2.3 Macrophage Function in Development -- 3.3 Macrophages and Inflammation -- 3.3.1 The Wound-Healing Process -- 3.3.2 Macrophages in Wound Healing -- 3.3.3 Regulation and Functional Consequences of Distinct Macrophage Phenotypes -- 3.3.4 Macrophage Phenotype Plasticity -- 3.4 Macrophage Interaction with Biomaterial Implants -- 3.4.1 Macrophage Recruitment to the Biomaterial Surface -- 3.4.2 Macrophage-Derived Foreign Body Giant Cells -- 3.4.3 Macrophages and Fibrosis.

3.5 Strategies to Target Macrophage Function and Polarization in the FBR -- 3.5.1 Macrophages and Biomaterial Biomimicry -- 3.5.2 Biomaterial Modulation of Macrophage Phenotype -- 3.5.3 Macrophage Spatiotemporal Distribution in the FBR -- 3.5.4 Engineering Macrophages to Modulate Inflammation During the FBR -- 3.6 Conclusions -- References -- Chapter 4: Understanding Nanoparticle Immunotoxicity to Develop Safe Medical Devices -- 4.1 Introduction -- 4.2 Hematological Compatibility -- 4.2.1 Hemolysis -- 4.2.2 Thrombogenicity -- 4.2.3 Anticoagulant Activity -- 4.2.4 Complement Activation -- 4.2.5 Protein "Corona" -- 4.3 Effects on the Immune Cell Function -- 4.4 Preclinical Characterization -- 4.4.1 Sterility and Endotoxin -- 4.4.2 Sterilization -- 4.5 Regulatory Considerations -- 4.6 Conclusions -- References -- Chapter 5: Host Response to Synthetic Versus Natural Biomaterials -- 5.1 Introduction -- 5.2 Natural Biomaterials -- 5.2.1 Collagen -- 5.2.2 Gelatin -- 5.2.3 Chitosan -- 5.2.4 Hyaluronan -- 5.2.5 Heparin -- 5.2.6 Alginate -- 5.2.7 Silk -- 5.2.8 Decellularized Tissue Matrices -- 5.3 Synthetic Biomaterials -- 5.3.1 Polyglycolide or Polyglycolic Acid (PGA) -- 5.3.2 Polylactic Acid (PLA) -- 5.3.3 Polycaprolactone (PCL) -- 5.3.4 Polyurethane (PU) -- 5.3.5 Polytetrafluoroethylene (PTFE) -- 5.4 Important Biomaterial Characteristics in the Host Response -- 5.5 Strategies to Overcome and Modulate the Host Responses -- 5.5.1 Surface Modification -- 5.5.2 Surface Coatings -- 5.5.3 Delivery of Bioactive Molecules -- 5.6 Conclusions -- References -- Chapter 6: Convergence of Osteoimmunology and Immunomodulation for the Development and Assessment of Bone Biomaterials -- 6.1 Introduction -- 6.2 Immune Cells Regulate Bone Dynamics -- 6.3 Definition of the "Osteoimmunomodulation" Property.

6.4 The Need to Include Immune Cells When Evaluating Novel Bone Biomaterials -- 6.5 Development of "Smart" Bone Biomaterials to Manipulate Osteoimmunomodulation -- 6.6 Conclusions -- References -- Chapter 7: Modulation of Innate Immune Cells to Create Transplant Tolerance -- 7.1 Introduction -- 7.1.1 Elements of the Innate Immunity -- 7.1.1.1 Innate Molecular Sensors -- 7.1.1.2 Complement -- 7.1.1.3 Innate Immune Cells -- Natural Killer Cells -- Monocytes and Macrophages -- Dendritic Cells -- Other Innate Cells -- 7.1.2 Responses of Innate Cells to Transplants -- 7.1.2.1 Ischemia-Reperfusion Injury -- 7.1.2.2 Acute Transplant Rejection -- 7.1.2.3 Chronic Transplant Rejection -- 7.1.2.4 Transplant Tolerance -- 7.1.3 Future Considerations -- References -- Chapter 8: Inflammatory Cytokine Response to Titanium Surface Chemistry and Topography -- 8.1 Introduction -- 8.2 Implant Surface Modification to Enhance Osseointegration: Influence of Micro-Roughness, Nano-­Roughness and Hydrophilicity -- 8.3 Titanium and Macrophage Polarization -- 8.4 Macrophage Response to Titanium Surface Modification -- 8.5 Topography-Induced Changes in Macrophage Function -- 8.6 Conclusions -- References -- Chapter 9: The Biomechanical Environment and Impact on Tissue Fibrosis -- 9.1 Introduction -- 9.2 Tissue Fibrosis -- 9.3 Implants and Fibrous Capsules -- 9.4 Biomechanical Forces and Tissue Fibrosis -- 9.5 Effects of Tissue Mechanical Properties on Fibrosis -- 9.6 Effects of Mechanical Stretch/Tension on Tissue Fibrosis -- 9.7 Shear Stress and Fibrosis -- 9.8 Mechanical Forces and Inflammation -- 9.9 Transduction of Mechanical Signals -- 9.10 Integration of Mechanical and Biochemical Signals -- 9.11 Conclusions -- References -- Chapter 10: Advancing Islet Transplantation: From Donor to Engraftment -- 10.1 Introduction -- 10.2 Donor Factors -- 10.3 Metabolic Factors.

10.4 Pancreas Procurement and Preservation -- 10.5 Islet Cell Processing -- 10.5.1 Islet Isolation -- 10.5.2 Islet Purification -- 10.5.3 Islet Culture -- 10.5.4 Islet Cell Viability and Functional Assay -- 10.5.5 Islet Vascularization After Transplant -- References -- Chapter 11: Targeted Modulation of Macrophage Functionality by Nanotheranostics in Inflammatory Liver Disease and Cancer -- 11.1 Introduction -- 11.2 Role of Hepatic Macrophages in Inflammation and Cancer -- 11.3 Classifications of Nanomaterials and Nanotheranostics -- 11.4 Targeting of Hepatic Macrophages Using Nanotheranostics -- 11.5 Conclusions -- References -- Chapter 12: T-Cell Mediated Immunomodulation and Transplant Optimization -- 12.1 Introduction -- 12.2 T-Cell Immune Responses and Age -- 12.3 Allogeneic HSCT: The Paradigm and Spearhead of T-Cell Immunotherapy -- 12.4 T-Cell Responses to Implants and Scaffolds: Challenges and Options -- 12.5 Perspectives for Transplant Optimization -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2025. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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