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Oral health and general health are interconnected in a bidirectional way. Insufficient oral hygiene and dental care may worsen systemic diseases, while systemic conditions and related therapies can manifest through oral symptoms. This highlights the crucial role of dental prevention and care across all age groups, from children to older adults. Dentists are often the first to detect signs of systemic illness. Many patients use medications that can cause xerostomia, which significantly affects oral health. For this reason, regular dental check-ups combined with oral hygiene guidance remain essential preventive strategies. Furthermore, the COVID-19 pandemic underscored the importance of prevention, as the first wave forced reliance on urgent surgical interventions for patients with toothache. This experience reinforced the principle that preventing diseases, including those of the oral cavity, must always remain a priority. Submissions of high-quality original articles, systematic or narrative reviews, and case reports addressing interdisciplinary perspectives on oral health and disease prevention are part of this Special Issue.

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