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The use of animals in medical research has led to groundbreaking discoveries. From the development of vaccines and antibiotics to advances in organ transplantation and cancer therapies, experimental animal models have played a crucial role in shaping modern medicine. However, their use also raises ethical concerns, necessitating strict regulations, ethical review boards, and the application of the "3Rs" principle—Replacement, Reduction, and Refinement—to minimize animal suffering while maximizing scientific benefit. This book aims to provide an overview of the significance, applications, and ethical considerations surrounding various experimental animal models in medical research. By examining different model organisms, their strengths and limitations, and the evolving landscape of alternative methodologies, we seek to highlight the delicate balance between scientific progress and ethical responsibility. Hopefully, the experimental animal models discussed in this book will contribute to a deeper understanding of the role of animal models in medical research and inspire further advancements in both biomedical sciences and ethical research practices.

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eng

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