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This Special Issue of Pharmaceutics presents recent advances in the development and application of biopolymer-based nanosystems for drug delivery. The featured articles highlight innovative approaches to designing nanoscale carriers using natural and synthetic biopolymers, focusing on their ability to enhance bioavailability, control drug release, and achieve targeted delivery. Contributions explore a wide range of systems, including nanoparticles, micelles, hydrogels, and nanofibers, as well as their physicochemical characterization, biological performance, and potential clinical relevance. Together, these works demonstrate the versatility and promise of biopolymeric nanocarriers in modern therapeutics and pave the way for future developments in safe, effective, and sustainable drug delivery technologies.

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